Precision Particle Fabrication Technology

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How It Works:  The Basics

Precision Particle Fabrication model

Key Aspects

Continuous-flow, high-volume nozzle technology with precise control over key attributes responsible for controlled release, including size, composition, coating,  and materials.

  • Controlled diameter from 10 μm up to 1 mm
  • Production rates of kg/hr to kg/min, depending on the application

Flexible and customizable to accommodate almost any active ingredient:

  • Small molecules (hydrophilic and hydrophobic)
  • Macromolecules, polymers, nucleic acids, proteins
  • Chemotherapeutics, biologics

Proven capability to produce a variety of construction and release profiles:

  • Solids, microcapsules, porous spheres
  • Sustained, delayed, pulsatile release profiles

Additional Benefits

  • Seamlessly integrate into current processes
  • Complete encapsulation
  • Single-step process
  • Batch-to-batch reproducibility

Technology In Action

Scientific Papers

  • Berkland, C., K. Kim, et al. (2001). "Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions." J Control Release 73(1): 59-74.
  • Berkland, C., M. King, et al. (2002). "Precise control of PLG microsphere size provides enhanced control of drug release rate." J Control Release 82(1): 137-147.
  • Berkland, C., E. Pollauf, et al. (2004). "Uniform double-walled polymer microspheres of controllable shell thickness." J Control Release 96(1): 101-111.