“Compound solubility serves as a surrogate indicator of oral biopharmaceutical performance. Between infancy and adulthood, marked compositional changes in gastrointestinal (GI) fluids occur.” – Maharaj, et al. Pharm Res. 2016; 33: 52-71
Solubility is an important aspect in the development of oral drugs. It is especially important for developers to take into consideration during the development of oral pediatric drugs. Poorly soluble oral pediatric drugs can cause local tissue injury, reduced bioavailability and adverse events.