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From the Mouths of Babes: Solubility in Pediatric Oral Drugs

Amanda Stevenson-Grund - Friday, April 20, 2018

Compound solubility serves as a surrogate indicator of oral biopharmaceutical performance. Between infancy and adulthood, marked compositional changes in gastrointestinal (GI) fluids occur.” – Maharaj, et al. Pharm Res. 2016; 33: 52-71

Child swallows oral pediatric medication

Solubility is an important aspect in the development of oral drugs. It is especially important for developers to take into consideration during the development of oral pediatric drugs. Poorly soluble oral pediatric drugs can cause local tissue injury, reduced bioavailability and adverse events.

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Drug Delivery to the Small Intestine Can Lead to Big Results

Amanda Stevenson-Grund - Friday, March 23, 2018

The small intestine is the most common target site due to shortest transit time and a large surface area of specialized cells, microvilli, and associated microvessels for material absorption and transportation to the bloodstream.” – Sharpe, et al. Expert Opin Drug Deliv. 2014 Jun; 11(6): 901–915

A human's intestine

Small can be mighty, and the results of drug delivery to the small intestine give credence to this idea. There are many benefits of delivering drugs to the small intestine, including high surface area, ability to target drug delivery and short transit time.

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Intraympanic Injections Provide Local Delivery of Disease Fighting Drugs to the Inner Ear

Amanda Stevenson-Grund - Friday, October 13, 2017

Medicines, called antivirals, may decrease the risk of health problems and hearing loss in some infected babies who show signs of congenital CMV infection at birth.” – CDC, Cytomegalovirus (CMV) and Congenital CMV Infection. Accessed June 24, 2017

An ear represents antiviral, intratympanic drug delivery for cytomegalovirus

Cytomegalovirus can cause devastating long-term effects, such as hearing loss, for infants diagnosed with the disease. Physicians often use antiviral medication to treat cytomegalovirus by relying on systemic exposure of the drug to treat the infection. Emerging localized delivery approaches, such as intratympanic injection, offer the potential to provide incremental protection against the infection by delivering drugs directly to the inner ear.

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Diverse Responses to Cytomegalovirus Drive the Need for Population-Specific Treatment Approaches

Amanda Stevenson-Grund - Friday, September 29, 2017

Born This Way: Congenital Cytomegalovirus

Amanda Stevenson-Grund - Friday, September 15, 2017

About one out of every 200 babies are born with congenital CMV infection.”
CDC, Cytomegalovirus (CMV) and Congenital CMV Infection. Accessed May 6, 2017

Pediatric patients with congenital cytomegalovirus can experience physical disabilities

Most parents of newborn babies experience joy when welcoming a new member of the family. However, parents of children with congenital cytomegalovirus instead experience the fear that their children may be affected by the physical and intellectual disabilities that can accompany this disease. In very extreme cases, congenital cytomegalovirus can lead to death in newborns and young children.

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Strengthening Solubility: Advantages of Increased Drug Solubility

Amanda Stevenson-Grund - Friday, September 01, 2017

Poorly water-soluble drug candidates are becoming more prevalent. It has been estimated that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous media,”Gupta et al., Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems. ISRN Pharmaceutics: 2013; 2013


Poorly water soluble drugs continue to pose significant formulation challenges. Solubility challenges have driven CDMOs to employ a portfolio of technologies to address solubility challenges. 

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Obviously Orodispersible: When ODTs are a Good Fit

Amanda Stevenson-Grund - Friday, August 11, 2017

Orodispersible tablets (ODT) can be administered to any patients having difficulty in swallowing.” – Hannan, et al. Indian J Pharm Sci. 2016; 78: 2-7

A pediatric patient with dysphagia and low medication adherence takes an orodispersible tablet (ODT).

Demand for patient-friendly formulations is increasing to address the diverse needs of multiple patient populations. As demand increases, pharmaceutical companies continue to look for innovative solutions to meet a broad range of patient needs. Orodispersible tablets (ODTs) can be a good fit for pediatric patients, geriatric patients and patients with dysphagia, as well as patients with low medication adherence.

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The Role of Odor in Taste-masking Is Nothing to Sniff At

Amanda Stevenson-Grund - Friday, January 27, 2017

Aroma (odor) is a strong determinant of taste perception. The preparation is of little therapeutic value if the patient can't get it beyond his nose.” – Pharmaceutical Care Laboratory at UNC Eshelman School of Pharmacy. Aesthetic Considerations of Oral Liquid Dosage Forms: Palatability

Child holds nose to avoid odor and help palatability of bad tasting medicine

“The brain can process approximately 10,000 different smells in an area the size of a postage stamp,” according to the Sense of Smell Lab. Despite such a talent, the way we process odor and the role of odor in our lives is sometimes overlooked. Unfortunately for patients, the role of odor is also sometimes overlooked in the taste-masking process. Odor plays a large role in palatability. Therefore, odor should also play a large role in taste-masking.

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More Than Skin-deep: Challenges in Treating Skin and Soft Tissue Infections

Amanda Stevenson-Grund - Friday, December 02, 2016

Skin and soft tissue infections (SSTIs) are ubiquitous and the most common of infections, suffered by everyone at some point to a lesser or greater degree and encountered by all doctors.” – Dryden, J. Antimicrob. Chemother. 2010: 65 (suppl 3): iii35-iii44

A patient with a skin or soft tissue infection is seen by a physician

Skin is the human body’s largest organ. It’s a “fun fact” that many children learn. What many children don’t learn about, however, are skin and soft tissue infections, which can affect both adults and children. Skin and soft tissue infections can become serious if not treated promptly, but some of the medications used to treat such infections, such as clindamycin, can lead to noncompliance, especially in children.

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Drinking Age: Child-appropriate Treatment for Pediatric Asthma

Amanda Stevenson-Grund - Friday, November 18, 2016

In the United States, asthma affects 22 million people. It is the most common chronic disease of childhood. Today, 6 million children have asthma.”
Tinkelman and Covar, National Jewish Health. Pediatric Asthma Overview.

A child with pediatric asthma may require prednisone

When it comes to alcohol, many teenagers and young adults look forward to the day they are old enough to legally drink. When it comes to medication, many physicians and caregivers look forward to the day the patients are old enough to stop drinking and start taking solid formulations, such as tablets and capsules, instead. Tablets and capsules are typically not age-appropriate for pediatric patients, especially children with asthma.

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