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The Modified-Release Panacea: Multiparticulates

Amanda Stevenson-Grund - Friday, December 01, 2017

Among all the systems used for controlled release, multiparticulate systems are the most commonly used and can offer many unique advantages.” – Wen and Park, editors. Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice. John Wiley & Sons, 2011.

 Round spheres represent multiparticulates in drug delivery

Modified-release dosage forms have many formats: extended release, delayed release, sustained release, targeted release and pulsatile release. Each of these release profiles has potential drug formats to support creating the correct pharmacokinetic curve. Multiparticulates, in particular, are well-suited for modified-release applications. As stated by Jagdale, et al.,Multiparticulate systems offer various advantages over single unit systems.  These advantages include no risk of dose dumping, flexibility of blending units with different release patterns, as well as short and reproducible gastric residence times.”

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Intraympanic Injections Provide Local Delivery of Disease Fighting Drugs to the Inner Ear

Amanda Stevenson-Grund - Friday, October 13, 2017

Medicines, called antivirals, may decrease the risk of health problems and hearing loss in some infected babies who show signs of congenital CMV infection at birth.” – CDC, Cytomegalovirus (CMV) and Congenital CMV Infection. Accessed June 24, 2017

An ear represents antiviral, intratympanic drug delivery for cytomegalovirus

Cytomegalovirus can cause devastating long-term effects, such as hearing loss, for infants diagnosed with the disease. Physicians often use antiviral medication to treat cytomegalovirus by relying on systemic exposure of the drug to treat the infection. Emerging localized delivery approaches, such as intratympanic injection, offer the potential to provide incremental protection against the infection by delivering drugs directly to the inner ear.

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Strengthening Solubility: Advantages of Increased Drug Solubility

Amanda Stevenson-Grund - Friday, September 01, 2017

Poorly water-soluble drug candidates are becoming more prevalent. It has been estimated that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous media,”Gupta et al., Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems. ISRN Pharmaceutics: 2013; 2013


Poorly water soluble drugs continue to pose significant formulation challenges. Solubility challenges have driven CDMOs to employ a portfolio of technologies to address solubility challenges. 

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We Go Together Like Parenteral Drug Delivery and Certain Drug Properties

Amanda Stevenson-Grund - Friday, June 30, 2017

“Parenteral drug administration, in which a drug is introduced directly across the body’s barrier defenses into the systemic circulation or some other tissue space, immediately overcomes barriers that can limit the effectiveness of orally administered drugs.” - Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Edited by David E. Golan, Lippincott Williams & Wilkins, 2008

A syringe represents drug delivery in parenteral drugs

Peanut butter and jelly, peas and carrots, Kirk and Spock – all are common examples of great combinations. A great pairing is also important when it comes to parenteral drug delivery and the medications delivered via this route. Drugs that are well-suited for parenteral drug delivery are those that are not bioavailable when administered orally, that are destroyed by digestive enzymes or that are irritating when delivered via other routes of administration.

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Your Best Shot: Types of Parenteral Drug Delivery Methods

Amanda Stevenson-Grund - Friday, June 16, 2017

Injections are among the most common health care procedures throughout the world, with at least 16 billion administered in developing and transitional countries each year.”
Jin, et al. Patient Prefer Adherence. 2015; 9: 923

A syringe represents the types of parenteral drugs in drug delivery

A big shot is someone important. However, in the medical field, all types of shots, or injectable or parenteral administration methods, are important. The three most common types of parenteral drugs are intramuscular, subcutaneous and intravenous.

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Perfectly Parenteral: Advantages of Parenteral Drug Delivery

Amanda Stevenson-Grund - Friday, June 02, 2017

The evident advantages of parenteral injection are the reliability and precision of dosage and the generally rapid onset of action of the drug,” – Schou, “Chapter 4: Subcutaneous and Intramuscular Injection of Drugs.” Concepts in Biochemical Pharmacology, Part 1. 1971; 28: 47

A parenteral drug like this one can improve adherence

Patients and caregivers of patients who are afraid of needles may wonder why any medication is given in the form of shots. However, parenteral drug delivery has unique advantages. Parenteral drugs can improve adherence, act immediately and allow the administrator to control drug delivery.

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When Your Number 1 Priority Is Type 2: Type 2 Diabetes Challenges

Amanda Stevenson-Grund - Friday, November 20, 2015

“In type 2 diabetes, it becomes increasingly difficult for the body’s cells to absorb and use the insulin. Type 2 diabetes is much more common than type 1 diabetes. About 90 % of people who have diabetes have type 2 diabetes.” – PubMed Health. Type 2 Diabetes Overview. 2014

Glasses magnify the phrase Diabetes type 2 on a page

Put the oxygen mask on yourself before helping others with theirs. You have to love yourself before you can love someone else. Reminders to make oneself a priority are abundant in our society because it's challenging to take care of oneself in the bustle of a busy life. There are extra challenges for people with type 2 diabetes mellitus, who often experience nerve damage and dysphagia.

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Shot Down: Obstacles That Hinder Vaccines in Developing Nations

Amanda Stevenson-Grund - Friday, July 17, 2015

Immunisation helps avert an estimated 2.5 million child deaths each year, as well as millions more bouts of illness and disability.
Access Campaign, Giving Developing Countries the Best Shot: an Overview of Vaccine Access and R&D. 2010

A syring lies on a map of Africa, representing the vaccines needed in developing nations, such as those in Africa 

A child dies every 20 seconds from a vaccine-preventable disease, and more than 70% of those children live in 10 countries, mostly in Asia and Africa, according to UNICEF. Despite the importance of vaccines, vaccine administration rates remain low in many countries. In addition to the usual obstacles to accessing healthcare in developing nations, vaccine administration comes with its own set of challenges, which include cost, transportation and storage and multiple doses.

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The New Control Group: Types of Controlled-release Drugs

Amanda Stevenson-Grund - Friday, April 10, 2015

Controlled drug delivery is one which delivers the drug at a predetermined rate, for locally or systemically, for a specified period of time … Such systems offer numerous advantages over traditional methods of drug delivery, including tailoring of drug release rates, protection of fragile drugs and increased patient comfort and compliance.”Bhowmik et al., The Pharma Innovation. 2012; 1: p24

An open capsule reveals medication inside 

Most people like to feel in control of their lives. Similarly, most patients and physicians like to feel in control of patient health. That’s why pharmaceutical companies create controlled-release drugs, medications whose active ingredient releases at a prespecified time. Three types of controlled-release medications include pulse-release, extended-release and delayed-release drugs.

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Harden Your Hearts: the Facts about Coronary Ischemia

Amanda Stevenson-Grund - Friday, March 06, 2015

Coronary heart disease costs the US $108.9 billion each year and is the most common type of heart disease.
Nichols, Medical News Today. What are the top 10 leading causes of death in the US? 2014

Man clutches at heart in chest pain 

Ischemic heart disease is the most common cause of death in the world and has been for the past decade. Coronary ischemia killed 7.4 million people in 2012 alone, according to the World Health Organization. Despite its prevalence both globally and in the United States, coronary ischemia, its causes and its treatments are not widely known by the American public.

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