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Enteric Drug Delivery Coating Techniques

Amanda Stevenson-Grund - Friday, March 09, 2018

Enteric-coated products are designed to remain intact in the acidic juices of the stomach and then to release the drug at the higher pH of the small intestine (above pH 5.5) or at the even higher pH in the colon (above pH 6.5): the drug effectiveness would be reduced by stomach acids and enzymes if left unprotected.” – Dalmoro et al., AAPS PharmSciTech. 2010 Dec; 11: 1500–1507

An image represents enteric drug delivery

A common issue with active pharmaceutical ingredients (APIs) is their inability to withstand the harsh environment of the stomach acids. Enteric coating saves the API from being harmed by the gastric environment. This paramount step in creating a viable final product often takes multiple steps to achieve. 

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Poorly Soluble Drugs: The New Norm?

Amanda Stevenson-Grund - Thursday, February 22, 2018

An estimated 40% of approved drugs and nearly 90% of the developmental pipeline drugs consist of poorly soluble molecules. Several marketed drugs suffer from poor solubility.” – Kalepu and Nekkanti, Acta Pharmaceutica Sinica B. 2015; 5: 442

Circles represent drugs with improved solubility

Poor solubility affects the ability of a drug to be absorbed by the body, limiting the amount of drug available to create the intended action on the body. In the Biopharmaceutics Classification System (BCS), classes II and IV include poorly soluble drugs. According to a 2013 review article in the Journal of Developing Drugs, 38 percent of the top 200 oral drugs in the U.S. fall into BCS classes II and IV. Parenteral drugs also run into issues with solubility and overall, around 40 percent of all New Chemical Entities (NCEs) have poor solubility. For NCEs, poor solubility can result in drug development failure. Although this issue may seem insurmountable, there are techniques to improve solubility through the drug product or drug product intermediate’s formulation.

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Multiparticulate Dosage Forms Reduce Dose Dumping, Limiting Adverse Events

Amanda Stevenson-Grund - Friday, February 02, 2018

Multi-particulate dosage forms have several therapeutic and technological advantages over single-unit dosage forms, they can distribute evenly in the gastrointestinal tract, resulting in fewer adverse effects.” - Martínez-Terán et al. Pediatr Ther. 2017; 7:314

 A person clutches his or her stomach, representing adverse events

Even the best medications can have negative effects that affect a patient’s quality of life. However, your drug product’s format can positively affect the adverse event profile decreasing adverse events.

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Orbis Biosciences Announces Licensing Agreement with Reckitt Benckiser

Amanda Stevenson-Grund - Tuesday, January 02, 2018

Orbis Biosciences logo


Orbis Biosciences, Inc. announced today that it has entered into an exclusive global license agreement leveraging its Precision Particle Fabrication® technology. Reckitt Benckiser (RB), world-leading Consumer Healthcare company, and Orbis have entered into an exclusive cooperation agreement to develop and commercialize novel technologies in the field of consumer healthcare. The technology will enable new products for a leading segment of RB's product portfolio. Detailed financial terms were not disclosed.

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Orbis Biosciences awarded CPhI Excellence in Formulation Award

Amanda Stevenson-Grund - Monday, October 30, 2017

Orbis Biosciences receives a CPhI Pharma Excellence in Pharma Award

CPhI Worldwide, the world’s leading pharmaceutical and manufacturing conference, hosted more than 42,000 visitors October 24 -26 in Frankfurt, Germany. The event, which included more than 2,500 exhibitors from 153 countries, represents every sector of the pharmaceutical market. The culmination of this conference is the CPhI Excellence in Pharma Awards Gala where key industry innovations are recognized from across the globe for their innovative technologies.

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The Power of Powder: Dispersible Powder and Its Many Formats

Amanda Stevenson-Grund - Friday, July 28, 2017

Powders and granules may be given to children from birth provided they can be administered as a liquid preparation.” – European Medicines Agency, Guideline on pharmaceutical development of medicines for paediatric use. 2013: 7

Medication in powder format

Powder medications predominate in many countries, such as Finland and Italy, and are starting to grow in popularity in the United States, according to Brion et al. in Acta Paediatrica. The power of powder lies in its many formats and kid-friendly features.

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Sachets Are Working Out in Drug Delivery

Amanda Stevenson-Grund - Friday, May 19, 2017

It is no wonder, then, that by 2018, up to 50 percent of all flexible pharmaceutical packaging will be in sachet or stick pack format.” – Bühler. Packaging Europe. 2015

Sachets are a flexible form of drug delivery

Sachets are the gymnasts of drug administration. This is because sachets are a flexible form of drug delivery. Their contents can go into food, hot drinks and feeding tubes.

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The Sense in Sachets

Amanda Stevenson-Grund - Friday, May 05, 2017

A key reason sachet packed medication is the fastest growing Dose Administration Aid (DAA) in the world, is that they offer a range of benefits which aged-care operators and community customers consider important.Amcal Chempro Chemists. Packing. Accessed August 31, 2016

A sachet for use in drug delivery

Sachets are a growing trend in drug delivery right now and for good reason. There are many benefits to using sachets in drug delivery. Three reasons drug developers use sachets are the allowance for high doses, format flexibility and minimization of harm during drug crushing.

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Sachets in Drug Delivery - A Growing Trend

Amanda Stevenson-Grund - Friday, April 21, 2017

“Companies are increasingly focusing on the development of orally disintegrating tablets (ODTs) and other novel methods of oral drug delivery. There is also a growing trend towards the formulation of sachets.” – Research and Markets, Global Pharmaceutical Excipients Market 2016-2021 – Type, Functionality, Formulation Analysis of the $8.1 Billion Industry. 2016

Sachets are a growing trend in drug delivery

“Disruptive” is the current business jargon for a product or service that changes a market. Most organizations want to “disrupt” their industries, with the hope it will affect the market permanently. In healthcare, an example is the increasing use of sachets in drug delivery. Sachets are now being used to treat all types of diseases, from the common cold to solid tumor cancers.

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Danger’s in the Air: Drug Fines Pose a Threat to Healthcare Workers

Amanda Stevenson-Grund - Friday, March 24, 2017

The size of particles is directly linked to their potential for causing health problems. Small particles less than 10 micrometers in diameter pose the greatest problems, because they can get deep into your lungs, and some may even get into your bloodstream.
 
United States Environmental Protection Agency, Particulate Matter. Health.

The inhalation of medication fines can affect lung function, affect a pregnancy and disrupt systemic vascular function.

“Take a deep breath” is sometimes said in times of stress. However, taking a deep breath could be dangerous for physicians and caregivers exposed to multiparticulate drug fines. The inhalation of drug fines can not only cause irritation and work-disrupting symptoms but also pose real danger to one’s health. The inhalation of medication fines can affect lung function, affect a pregnancy and disrupt systemic vascular function.

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