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From the Mouths of Babes: Solubility in Pediatric Oral Drugs

Amanda Stevenson-Grund - Friday, April 20, 2018

Compound solubility serves as a surrogate indicator of oral biopharmaceutical performance. Between infancy and adulthood, marked compositional changes in gastrointestinal (GI) fluids occur.” – Maharaj, et al. Pharm Res. 2016; 33: 52-71

Child swallows oral pediatric medication

Solubility is an important aspect in the development of oral drugs. It is especially important for developers to take into consideration during the development of oral pediatric drugs. Poorly soluble oral pediatric drugs can cause local tissue injury, reduced bioavailability and adverse events.

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No Sugar-coating Needed: GI Disorders Need Enteric Coating

Amanda Stevenson-Grund - Friday, April 06, 2018

Enteric coatings are used to reduce gastrointestinal side effects and control the release properties of oral medications.” – Niwa, et al. Pharm Res. 2014; 31: 2140

This image represents the need for enteric coating.

There are many drug-delivery techniques, and each one has its strengths. One technique is enteric coating. Enteric coating is best for use with active ingredients that treat gastrointestinal (GI) disorders, such as ulcerative colitis, Crohn’s disease and irritable bowel syndrome.

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Drug Delivery to the Small Intestine Can Lead to Big Results

Amanda Stevenson-Grund - Friday, March 23, 2018

The small intestine is the most common target site due to shortest transit time and a large surface area of specialized cells, microvilli, and associated microvessels for material absorption and transportation to the bloodstream.” – Sharpe, et al. Expert Opin Drug Deliv. 2014 Jun; 11(6): 901–915

A human's intestine

Small can be mighty, and the results of drug delivery to the small intestine give credence to this idea. There are many benefits of delivering drugs to the small intestine, including high surface area, ability to target drug delivery and short transit time.

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The Modified-Release Panacea: Multiparticulates

Amanda Stevenson-Grund - Friday, December 01, 2017

Among all the systems used for controlled release, multiparticulate systems are the most commonly used and can offer many unique advantages.” – Wen and Park, editors. Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice. John Wiley & Sons, 2011.

 Round spheres represent multiparticulates in drug delivery

Modified-release dosage forms have many formats: extended release, delayed release, sustained release, targeted release and pulsatile release. Each of these release profiles has potential drug formats to support creating the correct pharmacokinetic curve. Multiparticulates, in particular, are well-suited for modified-release applications. As stated by Jagdale, et al.,Multiparticulate systems offer various advantages over single unit systems.  These advantages include no risk of dose dumping, flexibility of blending units with different release patterns, as well as short and reproducible gastric residence times.”

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Intraympanic Injections Provide Local Delivery of Disease Fighting Drugs to the Inner Ear

Amanda Stevenson-Grund - Friday, October 13, 2017

Medicines, called antivirals, may decrease the risk of health problems and hearing loss in some infected babies who show signs of congenital CMV infection at birth.” – CDC, Cytomegalovirus (CMV) and Congenital CMV Infection. Accessed June 24, 2017

An ear represents antiviral, intratympanic drug delivery for cytomegalovirus

Cytomegalovirus can cause devastating long-term effects, such as hearing loss, for infants diagnosed with the disease. Physicians often use antiviral medication to treat cytomegalovirus by relying on systemic exposure of the drug to treat the infection. Emerging localized delivery approaches, such as intratympanic injection, offer the potential to provide incremental protection against the infection by delivering drugs directly to the inner ear.

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Strengthening Solubility: Advantages of Increased Drug Solubility

Amanda Stevenson-Grund - Friday, September 01, 2017

Poorly water-soluble drug candidates are becoming more prevalent. It has been estimated that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous media,”Gupta et al., Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems. ISRN Pharmaceutics: 2013; 2013


Poorly water soluble drugs continue to pose significant formulation challenges. Solubility challenges have driven CDMOs to employ a portfolio of technologies to address solubility challenges. 

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Cold Comfort: Treating the Common Cold

Amanda Stevenson-Grund - Friday, November 06, 2015

In the United States, the common cold is thought to account for approximately 75-100 million physician visits annually, with an economic impact of greater than $20 billion per year due to cold-related work loss.” – MedicineNet. Common Cold. 2015

A couple sick with the common cold blows their noses

“In the United States, colds account for more visits to the doctor than any other condition,” according to the American Lung Association. This shows that the name is not a misnomer, and the common cold really is a common problem. The common cold has no cure, and medicines that treat its symptoms are of short duration or are difficult to swallow.

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Hard to Swallow: Health Conditions That Cause Dysphagia

Amanda Stevenson-Grund - Friday, July 31, 2015

Dysphagia, or difficulty with swallowing, is a sorely neglected medical disorder that impacts as many as 15 million Americans, with approximately one million people annually receiving a new diagnosis of the condition.
VitalStim Therapy by Chattanooga Group. Dysphagia Fact Sheet. 2005

An older woman with dysphagia looks at large pills she'll have trouble swallowing 

Dysphagia is most common among elderly patients, but trouble swallowing is not isolated to the geriatric patient population. Dysphagia can be a side effect of other, serious health problems. Diseases and conditions that directly or indirectly cause difficulty swallowing are those that affect the brain or nervous system and those that affect the esophagus.

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Breathe Easy: the Orbis Solution to Nasal Polyps

Amanda Stevenson-Grund - Friday, June 05, 2015

Everyone with nasal polyps should try treatment with medicines, before considering surgery (unless there is any doubt about whether there is a more serious problem, such as tumour). Medicines for nasal polyps might be topical (for example, drops and sprays), or tablets.
Kenny and Knott, Patient. Nasal Polyps. 2014

A nasal spray sprays liquid into the air 

Typically, something that takes one’s breath away is amazing. Nasal polyps, however, can literally take away people’s breath by making it difficult to breathe. Nasal polyps are a common problem, but current treatment options are lacking.

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Sub-Saharan Africa, the Healthcare Desert

Amanda Stevenson-Grund - Friday, May 29, 2015

People in Sub-Saharan Africa have the worst health, on average, in the world. The region has 11 percent of the world’s population but carries 24 percent of the global disease burden.
International Finance Corporation, Sub-Saharan Africa. Health & Education in Africa

A barren desert stretches under a peaceful sky 

Sub-Saharan Africa, composed of more than 40 countries south of the Sahara desert, has a population of less than one billion people, but that number is expected to increase to more than 2 billion by 2050, according to CGIAR’s news blog. That’s almost a quarter of the world’s population. Even though so many people live in the region, many of the countries are still developing nations, and quality of life in those countries is poor, in part due to poor healthcare. Systemic challenges and specific diseases contribute to the poor healthcare of sub-Saharan Africa.

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