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Intraympanic Injections Provide Local Delivery of Disease Fighting Drugs to the Inner Ear

Amanda Stevenson-Grund - Friday, October 13, 2017

Medicines, called antivirals, may decrease the risk of health problems and hearing loss in some infected babies who show signs of congenital CMV infection at birth.” – CDC, Cytomegalovirus (CMV) and Congenital CMV Infection. Accessed June 24, 2017

An ear represents antiviral, intratympanic drug delivery for cytomegalovirus

Cytomegalovirus can cause devastating long-term effects, such as hearing loss, for infants diagnosed with the disease. Physicians often use antiviral medication to treat cytomegalovirus by relying on systemic exposure of the drug to treat the infection. Emerging localized delivery approaches, such as intratympanic injection, offer the potential to provide incremental protection against the infection by delivering drugs directly to the inner ear.

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Strengthening Solubility: Advantages of Increased Drug Solubility

Amanda Stevenson-Grund - Friday, September 01, 2017

Poorly water-soluble drug candidates are becoming more prevalent. It has been estimated that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous media,”Gupta et al., Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems. ISRN Pharmaceutics: 2013; 2013

 

Poorly water soluble drugs continue to pose significant formulation challenges. Solubility challenges have driven CDMOs to employ a portfolio of technologies to address solubility challenges. 

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Extended Release in Parenteral Drugs: Designed with Patients in Mind

Amanda Stevenson-Grund - Friday, July 14, 2017

Several solutions to the problem of discontinuous access to pharmacotherapy are being developed in the form of new, long-acting drug-delivery systems, which gradually release medication over a period of several days or weeks with a single application.” – Siegel, Psychiatry (Edgmont). 2005; 2: 22-31

 A patient holds an extended-release parenteral drug

Like a tailored suit, some things just fit well. This is true in pharmaceuticals. Drugs with certain characteristics are often a good fit for specific conditions and diseases. For example, extended-release parenteral drugs have many benefits, which make them good candidates for psychiatric conditions and chronic pain.

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We Go Together Like Parenteral Drug Delivery and Certain Drug Properties

Amanda Stevenson-Grund - Friday, June 30, 2017

“Parenteral drug administration, in which a drug is introduced directly across the body’s barrier defenses into the systemic circulation or some other tissue space, immediately overcomes barriers that can limit the effectiveness of orally administered drugs.” - Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Edited by David E. Golan, Lippincott Williams & Wilkins, 2008

A syringe represents drug delivery in parenteral drugs

Peanut butter and jelly, peas and carrots, Kirk and Spock – all are common examples of great combinations. A great pairing is also important when it comes to parenteral drug delivery and the medications delivered via this route. Drugs that are well-suited for parenteral drug delivery are those that are not bioavailable when administered orally, that are destroyed by digestive enzymes or that are irritating when delivered via other routes of administration.

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Your Best Shot: Types of Parenteral Drug Delivery Methods

Amanda Stevenson-Grund - Friday, June 16, 2017

Injections are among the most common health care procedures throughout the world, with at least 16 billion administered in developing and transitional countries each year.”
 –
Jin, et al. Patient Prefer Adherence. 2015; 9: 923

A syringe represents the types of parenteral drugs in drug delivery

A big shot is someone important. However, in the medical field, all types of shots, or injectable or parenteral administration methods, are important. The three most common types of parenteral drugs are intramuscular, subcutaneous and intravenous.

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Perfectly Parenteral: Advantages of Parenteral Drug Delivery

Amanda Stevenson-Grund - Friday, June 02, 2017

The evident advantages of parenteral injection are the reliability and precision of dosage and the generally rapid onset of action of the drug,” – Schou, “Chapter 4: Subcutaneous and Intramuscular Injection of Drugs.” Concepts in Biochemical Pharmacology, Part 1. 1971; 28: 47

A parenteral drug like this one can improve adherence

Patients and caregivers of patients who are afraid of needles may wonder why any medication is given in the form of shots. However, parenteral drug delivery has unique advantages. Parenteral drugs can improve adherence, act immediately and allow the administrator to control drug delivery.

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Putting Patients in Control: How Controlled-release Drugs Help Patients

Amanda Stevenson-Grund - Friday, April 07, 2017

Controlled-release (CR) drug-delivery systems continue to play an important role in the treatment of diseases” – Slew, Pharmaceutical Technology. 2014: 38

Controlled-release drugs help patients by reducing drug burst, reducing interruptions to daily life and improving medication adherence.

The Gettysburg address states that government should be “by the people, for the people.” Medication should also be created for the people. The best medicine is that developed for the specific needs of the patient. Controlled-release drugs help patients by reducing drug burst, reducing interruptions to daily life and improving medication adherence.

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Orbis is All Ears with Our Unisun Platform

Amanda Stevenson-Grund - Friday, February 10, 2017

In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery technologies to improve the effectiveness of inner ear drug therapy.” – Liu, et al. Acta Pharmaceutica Sinica B. 2013: 3; 86

 A physician looks at a patient's inner ear.

The inner ear is the size of a pencil eraser in circumference, according to the Hearing Institute Atlantic. When the small, delicate area experiences damage, it can be difficult to treat. There are, however, three types of inner ear treatments: systemic, intracochlear and intratympanic.

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Medication MATters in Opioid Addiction Treatment

Amanda Stevenson-Grund - Friday, April 08, 2016

Pharmacotherapies for opioid addiction, used in concert with behavioral therapies and other recovery support services (commonly referred to as ‘Medication-Assisted Treatment’ or ‘MAT’, have been shown to be highly effective in the treatment of opioid addiction.
American Society of Addiction Medicine. Advancing Access to Addiction Medications: 11

A collection of pills with a stop sign on top represents the treatment of opioid addiction.

The stereotypical addiction recovery involves a circle of current and former addicts talking about their lives. However, this is only one part of addiction, particularly when it comes to opioid addiction. Opioid addiction treatment includes not only behavioral therapy and support groups, but also additional medication. This combination is known as Medication-assisted Treatment (MAT). At least as important as the support groups, though not as well known to the general public, are the medications. Methadone, buprenorphine and naltrexone all treat opioid addiction, and naloxone can reverse an opioid overdose.

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Killing Kansans: Opioid Addiction in Our State

Amanda Stevenson-Grund - Friday, March 25, 2016

Opioid analgesics were a contributing factor in 22 (17.9%) of the poisoning deaths in 1999, rising to 127 (36.6%) of the poisoning deaths in 2009 … Since 2001, opioid analgesics have contributed to more deaths than heroin, cocaine, and benzodiazepine combined.
Kansas Health Statistics Report. 2012; 52: 1

Tablets, powder and a syringe represent opioid addiction in Kansas.

Opioid overuse is higher in the Midwest than in any other reason. The region’s rate of hospital inpatient stays related to opioid use has increased by 9.1% each year since 1993, according to a 2014 brief from the Healthcare Cost and Utilization Project. Opioid addiction levels in Kansas have been rising, too. However, the state could lower opioid misuse by implementing abuse-deterrent measures.

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