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Pet Peeve: a Need for Long-lasting Pain-relief Medication for Dogs and Cats

Amanda Stevenson-Grund - Friday, July 04, 2014

“Bernadine Cruz, DVM, a member of the American Veterinary Medical Association (AVMA), finds that between half and two-thirds of her clients give the medication she prescribes to their pets, but fall off after about six months.”
Till L. A Bitter Pill to Swallow. Veterinary Advantage Companion. September/October 2009; 1 (5)


Dogs are known as man’s best friends. Their feline counterparts are equally loved. In 63.2% of households in the United States, pet owners view their pets as family members, according to the American Medical Veterinary Association. Many pet owners would do as much for a sick pet as they would for a sick human family member if they could, but the lack of appropriate, available pet medications sometimes makes that difficult. Currently, there is a need for extended-release pain-relief medication for cats and dogs.

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Saving Your Bacon: Using Precision Particle Fabrication Technology™ to Prevent H1N1

Amanda Stevenson-Grund - Friday, June 27, 2014

“ … veterinary vaccines currently account for 26% of the global market in veterinary medicines, reflecting the importance of vaccines in animal health … In 2010, the number of food-producing animals was estimated to be roughly 20 billion and is rising gradually.”
Pastoret, Bull Acad Natl Med. 2012 Mar;196(3):589-90, 619-20


H1N1 has been a well-publicized influenza virus because a strain of it resulted in the 2009 pandemic that hospitalized 9,079 people and killed 593 between April and August in the United States alone. Although the first case of it in a pig was not confirmed until October of 2009, according to the CDC, the virus still exists in swine in the United States and is likely to continue to spread through pig-to-pig contact.

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Taste and See: Making Bad-tasting Drugs Not Taste at All

Amanda Stevenson-Grund - Friday, June 20, 2014

“Masking the bitter taste of drugs is a potential tool for the improvement of patient compliance which in turn decides the commercial success of the product.”
Patel et al., Drug Discov Ther. 2013: 1(5); 39


Oral taste-masking formulations are of great importance because some Active Pharmaceutical Ingredients (APIs) are extremely unpleasant to ingest from a palatability standpoint. The only way to rid the API of its inherent foul taste is to cover, or “mask,” it with something that tastes considerably better, and sometimes that isn’t even enough.

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Rational Food: Precision Particle Fabrication Technology™ Creates Long-lasting Field Rations

Amanda Stevenson-Grund - Friday, June 13, 2014

“During Operations Desert Shield and Storm in 1990 and 1991, Army Gen. Colin Powell, chairman of the Joint Chiefs of Staff at the time, reportedly was so dissatisfied with the state of MREs that he summoned the director of the combat feeding program to his office. As the story goes, Powell held up an MRE and rendered the simple order: ‘Fix it.’”
-Miles, Donna. Combat Rations Change to Reflect Troops’ Palates. 2012. American Forces Press Service


The Meal, Ready-to-Eat (MRE) platform is a self-contained, individual field ration that is the cornerstone of military subsistence used in combat or other field conditions where organized food facilities are not available. Combat ration intermediate moisture (IM) products (e.g. sandwiches) are designed to be consumed while on the move with little preparation needed. They are required to be shelf-stable for three years at 80⁰F or six months at 100⁰F.

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Under Control: Benefits of Controlled-release Drug Reformulations

Amanda Stevenson-Grund - Friday, June 06, 2014

We next discuss a comprehensive database that we have assembled, which includes more than four hundred prescription pharmaceutical reformulations from 1995 through April 2009 ... twenty- two reformulations involved switches to extended-release products or combination products in advance of generic entry for brand products with an additional $15.8 billion in annual sales.
-Shadowen, et al, Anticompetitive Product Changes in the Pharmaceutical Industry (October 10, 2010). Rutgers Law Journal, 2009; 41(1-2)


The term “controlled release” is taking on a new meaning.  At OrbisTM Biosciences, we use our Precision Particle FabricationTM technology to exploit the benefits of creating microsphere-based reformulations of existing drugs. A controlled-release drug reformulation can improve the product efficacy and extend patent protection.

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The Road to Recovery is Paved with Long-lasting, Systemic Analgesics

Amanda Stevenson-Grund - Friday, May 30, 2014

Pain was the most commonly reported reason for return [to the hospital after same-day surgery], occurring in … (38%) patients who had an unanticipated admission or readmission.”
Coley et al. J Clin Anesth. 2002; 14(5): 349

When it comes to pain management in the postoperative setting, 69% of patients experienced moderate, severe or extreme pain. Physicians can use systemic analgesics to relieve pain temporarily after surgery, but currently, there are no safe, long-acting systemic analgesics that provide baseline pain relief. Through our StratµmTM technology, we have created a single-injection, multi-day extended-release formulation of tramadol to simplify postoperative pain management. Our formulation will improve compliance and reduce the need for potent opioids. More >

Optimµm Technology™: Keeping Medicine Short and Sweet

Amanda Stevenson-Grund - Friday, May 23, 2014

"Difficulty administering oral corticosteroids to young children who are required to take these medications as part of their … treatment has been a concern among health care providers for many years. This problem is due in part to the bad taste associated with these preparations. Palatability is important to consider …”
-Hutto and Bratton. J Pediatr Oncol Nurs. 1999 Apr; 16(2): 74-7

A spoonful of sugar helps the medicine go down. So says Mary Poppins. Parents and pediatricians, however, know that taste masking goes beyond sugar, and the problems in pediatric medicine don’t end at palatability. Prednisone, for example, is a particularly foul-tasting corticosteroid, but pediatricians still commonly prescribe it for asthma, bronchiolitis, eczema, and other conditions.

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Bettering the lives of others one day at a time

Nate Dormer - Monday, July 09, 2012

Back in 2008 The Ewing Marion Kauffman Foundation announced they would grant The University of Kansas $8.1 million to establish the Institute for Advancing Medical Innovation (IAMI) with a goal of “providing people with a better quality of life” by “accelerating new drug therapies and medical devices to patients." More >

So you think you know K.C.?

Nate Dormer - Monday, June 11, 2012

If you asked people around the country what comes to mind when they think of Kansas City, you might expect to hear about the city’s world-class barbeque and elegant fountains (2nd most per capita in the world, behind only Rome).  According to a new study in the trade journal Contract Pharma, you can now add pharmaceutical contract research organizations (CROs) to the list. More >

Welcome to our new website

Nate Dormer - Sunday, January 15, 2012

Hello and welcome to the new Orbis Biosciences website! We've improved the look and content of the site to make it easier for you to understand how Orbis' Precision Particle Fabrication technology can help you develop your next-generation controlled-release products.  More >