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Drug Delivery to the Small Intestine Can Lead to Big Results

Amanda Stevenson-Grund - Friday, March 23, 2018

The small intestine is the most common target site due to shortest transit time and a large surface area of specialized cells, microvilli, and associated microvessels for material absorption and transportation to the bloodstream.” – Sharpe, et al. Expert Opin Drug Deliv. 2014 Jun; 11(6): 901–915

A human's intestine

Small can be mighty, and the results of drug delivery to the small intestine give credence to this idea. There are many benefits of delivering drugs to the small intestine, including high surface area, ability to target drug delivery and short transit time.

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Orbis Biosciences and Daré Bioscience Collaborate to Advance Innovation for Women's Reproductive Health!

Amanda Stevenson-Grund - Monday, March 12, 2018

Dare Bioscience logo

LENEXA, KS – March 12, 2018 –

Orbis Biosciences, Inc. announced today it has granted Daré Bioscience, Inc. an exclusive option to license worldwide rights to Orbis’ long-acting contraceptive products.  This agreement leverages Orbis’ StratµmTM technology to create an etonogestrel contraceptive for 6- and 12-month durations.  The agreement includes pre-clinical studies and the option to enter into a license agreement for clinical development.  Financial terms were not disclosed. 

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Enteric Drug Delivery Coating Techniques

Amanda Stevenson-Grund - Friday, March 09, 2018

Enteric-coated products are designed to remain intact in the acidic juices of the stomach and then to release the drug at the higher pH of the small intestine (above pH 5.5) or at the even higher pH in the colon (above pH 6.5): the drug effectiveness would be reduced by stomach acids and enzymes if left unprotected.” – Dalmoro et al., AAPS PharmSciTech. 2010 Dec; 11: 1500–1507

An image represents enteric drug delivery

A common issue with active pharmaceutical ingredients (APIs) is their inability to withstand the harsh environment of the stomach acids. Enteric coating saves the API from being harmed by the gastric environment. This paramount step in creating a viable final product often takes multiple steps to achieve. 

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