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The Modified-Release Panacea: Multiparticulates

Amanda Stevenson-Grund - Friday, December 01, 2017

Among all the systems used for controlled release, multiparticulate systems are the most commonly used and can offer many unique advantages.” – Wen and Park, editors. Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice. John Wiley & Sons, 2011.

 Round spheres represent multiparticulates in drug delivery

Modified-release dosage forms have many formats: extended release, delayed release, sustained release, targeted release and pulsatile release. Each of these release profiles has potential drug formats to support creating the correct pharmacokinetic curve. Multiparticulates, in particular, are well-suited for modified-release applications. As stated by Jagdale, et al.,Multiparticulate systems offer various advantages over single unit systems.  These advantages include no risk of dose dumping, flexibility of blending units with different release patterns, as well as short and reproducible gastric residence times.”

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