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Standing Trial: Challenges of Pediatric Patients in Clinical Trials

Amanda Stevenson-Grund - Friday, January 29, 2016

“…a total of 426 drug labels have been revised with new paediatric information and an estimated 50 percent of drugs used in children have now been studied in children as compared to just 20 percent before the enactment of [the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act].” – Bohannon and Sietsema. Pharmaceutical Physician. 2012: 6

Tablets and capsules form the shape of a baby, representing pediatric clinical trials

In the past 10 years, there have been more studies involving pediatrics than there were in the 50 years prior, according to the 2012 special feature article. This increase is due to US legislation and the realization that clinical trials involving pediatric patients are important. There are ethical and practical challenges to the inclusion of pediatric patients in clinical trials. However, excluding pediatric patients from clinical trials can be harmful.

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Feeling Your Pain: Acute Pain vs. Chronic Pain

Amanda Stevenson-Grund - Friday, January 15, 2016

Both acute and chronic pain are an enormous problem in the United States, costing 650 million lost workdays and $65 billion a year.
Grichnik and Ferrante. Mt Sinai J Med. 1991; 58: 217

Woman in need of analgesic feels acute or chronic pain

The phrase, “a pain in the neck,” gets thrown around a lot, but actual pain, in the neck or elsewhere, should not be discussed so flippantly. There are two types of pain, acute and chronic. Acute pain and chronic pain are different, but both need more treatment options.

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Sprinkle, Sprinkle, Little Drugs

Amanda Stevenson-Grund - Monday, January 04, 2016

But, the effects of newer formulations, such as effervescent and chewable dosage forms, granules and sprinkles … are largely untested with regards to medication adherence.
Zuidgeest et al. Update on 2004 Background Paper, Priority Medications for Children. 2013

Sprinkles for drug delivery fill the screen

“Sprinkles,” to many, conjure up the image of flavorless colored dots to make ice cream look festive. In drug delivery, however, sprinkle medications are beads filled with API that patients can pour onto soft food and swallow if they have trouble swallowing full capsules. In order for sprinkle medications to be an effective drug delivery option for patients with dysphagia, they must follow certain parameters, such as size, bioavailability and ease of use.

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