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Intraympanic Injections Provide Local Delivery of Disease Fighting Drugs to the Inner Ear

Amanda Stevenson-Grund - Friday, October 13, 2017

Medicines, called antivirals, may decrease the risk of health problems and hearing loss in some infected babies who show signs of congenital CMV infection at birth.” – CDC, Cytomegalovirus (CMV) and Congenital CMV Infection. Accessed June 24, 2017

An ear represents antiviral, intratympanic drug delivery for cytomegalovirus

Cytomegalovirus can cause devastating long-term effects, such as hearing loss, for infants diagnosed with the disease. Physicians often use antiviral medication to treat cytomegalovirus by relying on systemic exposure of the drug to treat the infection. Emerging localized delivery approaches, such as intratympanic injection, offer the potential to provide incremental protection against the infection by delivering drugs directly to the inner ear.

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Diverse Responses to Cytomegalovirus Drive the Need for Population-Specific Treatment Approaches

Amanda Stevenson-Grund - Friday, September 29, 2017

Born This Way: Congenital Cytomegalovirus

Amanda Stevenson-Grund - Friday, September 15, 2017

About one out of every 200 babies are born with congenital CMV infection.”
 –
CDC, Cytomegalovirus (CMV) and Congenital CMV Infection. Accessed May 6, 2017

Pediatric patients with congenital cytomegalovirus can experience physical disabilities

Most parents of newborn babies experience joy when welcoming a new member of the family. However, parents of children with congenital cytomegalovirus instead experience the fear that their children may be affected by the physical and intellectual disabilities that can accompany this disease. In very extreme cases, congenital cytomegalovirus can lead to death in newborns and young children.

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Strengthening Solubility: Advantages of Increased Drug Solubility

Amanda Stevenson-Grund - Friday, September 01, 2017

Poorly water-soluble drug candidates are becoming more prevalent. It has been estimated that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous media,”Gupta et al., Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems. ISRN Pharmaceutics: 2013; 2013

 

Poorly water soluble drugs continue to pose significant formulation challenges. Solubility challenges have driven CDMOs to employ a portfolio of technologies to address solubility challenges. 

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Obviously Orodispersible: When ODTs are a Good Fit

Amanda Stevenson-Grund - Friday, August 11, 2017

Orodispersible tablets (ODT) can be administered to any patients having difficulty in swallowing.” – Hannan, et al. Indian J Pharm Sci. 2016; 78: 2-7

A pediatric patient with dysphagia and low medication adherence takes an orodispersible tablet (ODT).

Demand for patient-friendly formulations is increasing to address the diverse needs of multiple patient populations. As demand increases, pharmaceutical companies continue to look for innovative solutions to meet a broad range of patient needs. Orodispersible tablets (ODTs) can be a good fit for pediatric patients, geriatric patients and patients with dysphagia, as well as patients with low medication adherence.

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The Power of Powder: Dispersible Powder and Its Many Formats

Amanda Stevenson-Grund - Friday, July 28, 2017

Powders and granules may be given to children from birth provided they can be administered as a liquid preparation.” – European Medicines Agency, Guideline on pharmaceutical development of medicines for paediatric use. 2013: 7

Medication in powder format

Powder medications predominate in many countries, such as Finland and Italy, and are starting to grow in popularity in the United States, according to Brion et al. in Acta Paediatrica. The power of powder lies in its many formats and kid-friendly features.

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Extended Release in Parenteral Drugs: Designed with Patients in Mind

Amanda Stevenson-Grund - Friday, July 14, 2017

Several solutions to the problem of discontinuous access to pharmacotherapy are being developed in the form of new, long-acting drug-delivery systems, which gradually release medication over a period of several days or weeks with a single application.” – Siegel, Psychiatry (Edgmont). 2005; 2: 22-31

 A patient holds an extended-release parenteral drug

Like a tailored suit, some things just fit well. This is true in pharmaceuticals. Drugs with certain characteristics are often a good fit for specific conditions and diseases. For example, extended-release parenteral drugs have many benefits, which make them good candidates for psychiatric conditions and chronic pain.

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We Go Together Like Parenteral Drug Delivery and Certain Drug Properties

Amanda Stevenson-Grund - Friday, June 30, 2017

“Parenteral drug administration, in which a drug is introduced directly across the body’s barrier defenses into the systemic circulation or some other tissue space, immediately overcomes barriers that can limit the effectiveness of orally administered drugs.” - Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Edited by David E. Golan, Lippincott Williams & Wilkins, 2008

A syringe represents drug delivery in parenteral drugs

Peanut butter and jelly, peas and carrots, Kirk and Spock – all are common examples of great combinations. A great pairing is also important when it comes to parenteral drug delivery and the medications delivered via this route. Drugs that are well-suited for parenteral drug delivery are those that are not bioavailable when administered orally, that are destroyed by digestive enzymes or that are irritating when delivered via other routes of administration.

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Your Best Shot: Types of Parenteral Drug Delivery Methods

Amanda Stevenson-Grund - Friday, June 16, 2017

Injections are among the most common health care procedures throughout the world, with at least 16 billion administered in developing and transitional countries each year.”
 –
Jin, et al. Patient Prefer Adherence. 2015; 9: 923

A syringe represents the types of parenteral drugs in drug delivery

A big shot is someone important. However, in the medical field, all types of shots, or injectable or parenteral administration methods, are important. The three most common types of parenteral drugs are intramuscular, subcutaneous and intravenous.

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Perfectly Parenteral: Advantages of Parenteral Drug Delivery

Amanda Stevenson-Grund - Friday, June 02, 2017

The evident advantages of parenteral injection are the reliability and precision of dosage and the generally rapid onset of action of the drug,” – Schou, “Chapter 4: Subcutaneous and Intramuscular Injection of Drugs.” Concepts in Biochemical Pharmacology, Part 1. 1971; 28: 47

A parenteral drug like this one can improve adherence

Patients and caregivers of patients who are afraid of needles may wonder why any medication is given in the form of shots. However, parenteral drug delivery has unique advantages. Parenteral drugs can improve adherence, act immediately and allow the administrator to control drug delivery.

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