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Sachets Are Working Out in Drug Delivery

Amanda Stevenson-Grund - Friday, May 19, 2017

It is no wonder, then, that by 2018, up to 50 percent of all flexible pharmaceutical packaging will be in sachet or stick pack format.” – Bühler. Packaging Europe. 2015

Sachets are a flexible form of drug delivery

Sachets are the gymnasts of drug administration. This is because sachets are a flexible form of drug delivery. Their contents can go into food, hot drinks and feeding tubes.

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The Sense in Sachets

Amanda Stevenson-Grund - Friday, May 05, 2017

A key reason sachet packed medication is the fastest growing Dose Administration Aid (DAA) in the world, is that they offer a range of benefits which aged-care operators and community customers consider important.Amcal Chempro Chemists. Packing. Accessed August 31, 2016

A sachet for use in drug delivery

Sachets are a growing trend in drug delivery right now and for good reason. There are many benefits to using sachets in drug delivery. Three reasons drug developers use sachets are the allowance for high doses, format flexibility and minimization of harm during drug crushing.

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Sachets in Drug Delivery - A Growing Trend

Amanda Stevenson-Grund - Friday, April 21, 2017

“Companies are increasingly focusing on the development of orally disintegrating tablets (ODTs) and other novel methods of oral drug delivery. There is also a growing trend towards the formulation of sachets.” – Research and Markets, Global Pharmaceutical Excipients Market 2016-2021 – Type, Functionality, Formulation Analysis of the $8.1 Billion Industry. 2016

Sachets are a growing trend in drug delivery

“Disruptive” is the current business jargon for a product or service that changes a market. Most organizations want to “disrupt” their industries, with the hope it will affect the market permanently. In healthcare, an example is the increasing use of sachets in drug delivery. Sachets are now being used to treat all types of diseases, from the common cold to solid tumor cancers.

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Putting Patients in Control: How Controlled-release Drugs Help Patients

Amanda Stevenson-Grund - Friday, April 07, 2017

Controlled-release (CR) drug-delivery systems continue to play an important role in the treatment of diseases” – Slew, Pharmaceutical Technology. 2014: 38

Controlled-release drugs help patients by reducing drug burst, reducing interruptions to daily life and improving medication adherence.

The Gettysburg address states that government should be “by the people, for the people.” Medication should also be created for the people. The best medicine is that developed for the specific needs of the patient. Controlled-release drugs help patients by reducing drug burst, reducing interruptions to daily life and improving medication adherence.

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Danger’s in the Air: Drug Fines Pose a Threat to Healthcare Workers

Amanda Stevenson-Grund - Friday, March 24, 2017

The size of particles is directly linked to their potential for causing health problems. Small particles less than 10 micrometers in diameter pose the greatest problems, because they can get deep into your lungs, and some may even get into your bloodstream.
 
United States Environmental Protection Agency, Particulate Matter. Health.

The inhalation of medication fines can affect lung function, affect a pregnancy and disrupt systemic vascular function.

“Take a deep breath” is sometimes said in times of stress. However, taking a deep breath could be dangerous for physicians and caregivers exposed to multiparticulate drug fines. The inhalation of drug fines can not only cause irritation and work-disrupting symptoms but also pose real danger to one’s health. The inhalation of medication fines can affect lung function, affect a pregnancy and disrupt systemic vascular function.

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Not Fine: How Drug Fines Affect Physicians and Caregivers

Amanda Stevenson-Grund - Friday, March 10, 2017

Occupational exposures to chemotherapy drugs may occur through inhalation, skin contact, skin absorption, ingestion, or injection. Inhalation and skin contact/absorption are the most likely routes of exposure.
 –
Couch and West, Health Hazard Evaluation Report. 2012; HETA 2009-0148-3158: 20

Comparison of Orbis Biosciences' uniform medication without fines to other medications with fines

Doctors and nurses wash their hands and take special precautions not to catch or spread patient illnesses. Sometimes, however, patient medications can also be dangerous. Many physicians and caregivers are exposed to drug fines in their workplaces. The accidental inhalation of such fines can cause irritation and symptoms that disrupt one’s work. 

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A Fine State of Affairs: Multiparticulate Drug Fines

Amanda Stevenson-Grund - Friday, February 24, 2017

Recent trends indicate that multiparticulate drug delivery systems are especially suitable for achieving controlled and delayed release oral formulations with low risk of dose dumping.
 – Gandhi and Baheti. Int J Pharmaceutical and Chemical Sciences. 2013: 2; 1620

Uniform particles compared to conventional ones like drug fines 

One of these things is not like the others. The song, from a children’s television program, is a simple one. However, the thought behind it can be applied to advanced medical technology. Uniform particles are important for safe and effective drug delivery. Drug particles of a different size or shape, such as multiparticulate drug fines, need to be removed for a medication to achieve its optimum effect.

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Orbis is All Ears with Our Unisun Platform

Amanda Stevenson-Grund - Friday, February 10, 2017

In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery technologies to improve the effectiveness of inner ear drug therapy.” – Liu, et al. Acta Pharmaceutica Sinica B. 2013: 3; 86

 A physician looks at a patient's inner ear.

The inner ear is the size of a pencil eraser in circumference, according to the Hearing Institute Atlantic. When the small, delicate area experiences damage, it can be difficult to treat. There are, however, three types of inner ear treatments: systemic, intracochlear and intratympanic.

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The Role of Odor in Taste-masking Is Nothing to Sniff At

Amanda Stevenson-Grund - Friday, January 27, 2017

Aroma (odor) is a strong determinant of taste perception. The preparation is of little therapeutic value if the patient can't get it beyond his nose.” – Pharmaceutical Care Laboratory at UNC Eshelman School of Pharmacy. Aesthetic Considerations of Oral Liquid Dosage Forms: Palatability

Child holds nose to avoid odor and help palatability of bad tasting medicine

“The brain can process approximately 10,000 different smells in an area the size of a postage stamp,” according to the Sense of Smell Lab. Despite such a talent, the way we process odor and the role of odor in our lives is sometimes overlooked. Unfortunately for patients, the role of odor is also sometimes overlooked in the taste-masking process. Odor plays a large role in palatability. Therefore, odor should also play a large role in taste-masking.

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To Be Continued? Batch vs. Continuous Manufacturing

Amanda Stevenson-Grund - Friday, January 13, 2017

The development of small-scale, continuous manufacturing systems will be one of the most significant changes in the pharmaceutical industry in the next 10 years.
Page, Pharmaceutical Technology Europe. 2014; 26

Continuous manufacturing vs. batch manufacturing

“Do continue,” we say to someone whose conversation has been cut short. Will we be saying that same phrase to members of the pharmaceutical industry? Continuous manufacturing, which the Parenteral Drug Association defines as “production or manufacturing processes that run with a continuous flow,” is increasing in the pharmaceutical industry. Continuous manufacturing can increase efficiency, lessen the need for large facilities and decrease waste. However, moving from batch manufacturing to continuous manufacturing can mean changing established processes, equipment and culture.

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