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Sachets in Drug Delivery - A Growing Trend

Amanda Stevenson-Grund - Friday, April 21, 2017

“Companies are increasingly focusing on the development of orally disintegrating tablets (ODTs) and other novel methods of oral drug delivery. There is also a growing trend towards the formulation of sachets.” – Research and Markets, Global Pharmaceutical Excipients Market 2016-2021 – Type, Functionality, Formulation Analysis of the $8.1 Billion Industry. 2016

Sachets are a growing trend in drug delivery

“Disruptive” is the current business jargon for a product or service that changes a market. Most organizations want to “disrupt” their industries, with the hope it will affect the market permanently. In healthcare, an example is the increasing use of sachets in drug delivery. Sachets are now being used to treat all types of diseases, from the common cold to solid tumor cancers.

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Putting Patients in Control: How Controlled-release Drugs Help Patients

Amanda Stevenson-Grund - Friday, April 07, 2017

Controlled-release (CR) drug-delivery systems continue to play an important role in the treatment of diseases” – Slew, Pharmaceutical Technology. 2014: 38

Controlled-release drugs help patients by reducing drug burst, reducing interruptions to daily life and improving medication adherence.

The Gettysburg address states that government should be “by the people, for the people.” Medication should also be created for the people. The best medicine is that developed for the specific needs of the patient. Controlled-release drugs help patients by reducing drug burst, reducing interruptions to daily life and improving medication adherence.

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Danger’s in the Air: Drug Fines Pose a Threat to Healthcare Workers

Amanda Stevenson-Grund - Friday, March 24, 2017

The size of particles is directly linked to their potential for causing health problems. Small particles less than 10 micrometers in diameter pose the greatest problems, because they can get deep into your lungs, and some may even get into your bloodstream.
United States Environmental Protection Agency, Particulate Matter. Health.

The inhalation of medication fines can affect lung function, affect a pregnancy and disrupt systemic vascular function.

“Take a deep breath” is sometimes said in times of stress. However, taking a deep breath could be dangerous for physicians and caregivers exposed to multiparticulate drug fines. The inhalation of drug fines can not only cause irritation and work-disrupting symptoms but also pose real danger to one’s health. The inhalation of medication fines can affect lung function, affect a pregnancy and disrupt systemic vascular function.

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Not Fine: How Drug Fines Affect Physicians and Caregivers

Amanda Stevenson-Grund - Friday, March 10, 2017

Occupational exposures to chemotherapy drugs may occur through inhalation, skin contact, skin absorption, ingestion, or injection. Inhalation and skin contact/absorption are the most likely routes of exposure.
Couch and West, Health Hazard Evaluation Report. 2012; HETA 2009-0148-3158: 20

Comparison of Orbis Biosciences' uniform medication without fines to other medications with fines

Doctors and nurses wash their hands and take special precautions not to catch or spread patient illnesses. Sometimes, however, patient medications can also be dangerous. Many physicians and caregivers are exposed to drug fines in their workplaces. The accidental inhalation of such fines can cause irritation and symptoms that disrupt one’s work. 

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A Fine State of Affairs: Multiparticulate Drug Fines

Amanda Stevenson-Grund - Friday, February 24, 2017

Recent trends indicate that multiparticulate drug delivery systems are especially suitable for achieving controlled and delayed release oral formulations with low risk of dose dumping.
 – Gandhi and Baheti. Int J Pharmaceutical and Chemical Sciences. 2013: 2; 1620

Uniform particles compared to conventional ones like drug fines 

One of these things is not like the others. The song, from a children’s television program, is a simple one. However, the thought behind it can be applied to advanced medical technology. Uniform particles are important for safe and effective drug delivery. Drug particles of a different size or shape, such as multiparticulate drug fines, need to be removed for a medication to achieve its optimum effect.

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Orbis is All Ears with Our Unisun Platform

Amanda Stevenson-Grund - Friday, February 10, 2017

In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery technologies to improve the effectiveness of inner ear drug therapy.” – Liu, et al. Acta Pharmaceutica Sinica B. 2013: 3; 86

 A physician looks at a patient's inner ear.

The inner ear is the size of a pencil eraser in circumference, according to the Hearing Institute Atlantic. When the small, delicate area experiences damage, it can be difficult to treat. There are, however, three types of inner ear treatments: systemic, intracochlear and intratympanic.

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The Role of Odor in Taste-masking Is Nothing to Sniff At

Amanda Stevenson-Grund - Friday, January 27, 2017

Aroma (odor) is a strong determinant of taste perception. The preparation is of little therapeutic value if the patient can't get it beyond his nose.” – Pharmaceutical Care Laboratory at UNC Eshelman School of Pharmacy. Aesthetic Considerations of Oral Liquid Dosage Forms: Palatability

Child holds nose to avoid odor and help palatability of bad tasting medicine

“The brain can process approximately 10,000 different smells in an area the size of a postage stamp,” according to the Sense of Smell Lab. Despite such a talent, the way we process odor and the role of odor in our lives is sometimes overlooked. Unfortunately for patients, the role of odor is also sometimes overlooked in the taste-masking process. Odor plays a large role in palatability. Therefore, odor should also play a large role in taste-masking.

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To Be Continued? Batch vs. Continuous Manufacturing

Amanda Stevenson-Grund - Friday, January 13, 2017

The development of small-scale, continuous manufacturing systems will be one of the most significant changes in the pharmaceutical industry in the next 10 years.
Page, Pharmaceutical Technology Europe. 2014; 26

Continuous manufacturing vs. batch manufacturing

“Do continue,” we say to someone whose conversation has been cut short. Will we be saying that same phrase to members of the pharmaceutical industry? Continuous manufacturing, which the Parenteral Drug Association defines as “production or manufacturing processes that run with a continuous flow,” is increasing in the pharmaceutical industry. Continuous manufacturing can increase efficiency, lessen the need for large facilities and decrease waste. However, moving from batch manufacturing to continuous manufacturing can mean changing established processes, equipment and culture.

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A Class Issue: Biopharmaceutics Classification System and Pediatrics

Amanda Stevenson-Grund - Friday, December 30, 2016

The applicability of the biopharmaceutics system to paediatric product development has yet to be explored.” – Batchelor, Int J Pharm. 2014; 469: 251

The Biopharmaceutics Classification System has flaws when it comes to pediatrics

In school, we’re taught that cutting class is bad. It certainly has negative consequences on one’s grade point average. However, cutting class as in dropping outdated classification systems can be beneficial. For example, the Biopharmaceutics Classification System (BCS) has flaws when it comes to pediatric drugs.

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The Danger Zone: Extemporaneous Formulations

Amanda Stevenson-Grund - Friday, December 16, 2016

Extemporaneous preparation is one of the highest risk activities carried out in pharmacy today and is often supported by a poor quality evidence base.
Lowey and Jackson, The Pharmaceutical Journal. 2008

Drugs represent the dangers of extemporaneous formulations

Journalists and police officials often report wanted suspects as “armed and dangerous.” The two words often come in a pair, but a situation doesn’t require arms to be dangerous. In the medical field, extemporaneous formulations can be dangerous due to the potential for incorrect dosing and a lack of information.

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